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To our best knowledge, this study is the first to investigate the effect of remimazolam on the oxidative stress response in patients undergoing thoracic surgery with OLV and the first study to show that the use of low-dose remimazolam for the maintenance of general anesthesia can increase the levels of SOD and GSH-Px and reduce oxidative stress reactions in these patients

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We and others have observed that enhanced de novo synthesis of serine and glycine from glucose reduces the reliance of cells on extracellular sources [43, 99]

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